Antifolate Drugs in Cancer Therapy (Cancer Drug Discovery by Ann L. Jackman

By Ann L. Jackman

Antifolates are a big category of anticancer medications initially built as anti leu kemic brokers, yet now used, often together with different medicines, for the remedy of quite a lot of tumors, particularly carcinomas of the pinnacle and neck, breast, germ phone tumors, non-Hodgkin's lymphoma, acute lymphoblastic leukemia, and osteogenic sar comas. 5-Fluorouracil and its prodrugs additionally goal, partly, the folate-dependent enzyme, thymidylate synthase. moreover, folate supplementation within the type of leucovorin, modulates 5-fluororuacil task. 5-Fluorouracil is commonly used within the therapy of colorectal and gastric melanoma and together for different strong tumors corresponding to breast and head and neck cancers. Ongoing medical trials with the more recent antifolates recommend that the diversity of sturdy tumors the place those brokers may be of use may perhaps increase additional. part a century in the past, fascinating medical and scientific discoveries prompt that folie acid used to be a diet inquisitive about important mobile metabolic tactics. The folate analogs, aminopterin and methotrexate, have been synthesized by way of the yank Cyanamid corporation in an try and intervene with those approaches and have been proven to have anticancer task through Farber and his colleagues. therefore, the primary of antimetabolite remedy for the therapy of melanoma was once demonstrated. Biomedical study over the next years resulted in a deeper realizing of the complicated biochemical pharmacology of folates and antifolates. Selective antimicrobial brokers have been chanced on, yet extra tumor-selective anticancer brokers didn't instantly emerge.

Show description

Read Online or Download Antifolate Drugs in Cancer Therapy (Cancer Drug Discovery and Development) PDF

Best pharmacology books

UCL Hospitals Injectable Medicines Administration Guide: Pharmacy Department

"I will surely suggest this e-book to all employees with an curiosity and involvement in intravenous drug treatment. "  —The Pharmaceutical magazine "There is not any doubt that nurses will locate this small publication useful.  it's going to be on hand for session in any scientific sector the place medicines are administered to sufferers by means of the injectable routes.

The Cleveland Clinic Manual of Headache Therapy

The Cleveland hospital guide of Headache treatment is a hands-on, sensible advisor to analysis, work-up, and remedy of universal headache problems. every one bankruptcy is written through a Cleveland health facility Headache middle care supplier. The publication makes use of an evidence-based method of sift throughout the wealth of accessible facts and determine the main acceptable remedies.

Drugs for HER-2-positive Breast Cancer (Milestones in Drug Therapy)

Progress issue receptors have lengthy been recognized to force malignant transformation and melanoma development. The epidermal development issue receptor (EGFR, ErbB, HER) approach is probably going the simplest defined membrane receptor tyrosine kinase kinfolk in malignant tumors. With implementation of the growth-inhibitory anti-HER-2 antibody trastuzumab (Herceptin) for the remedy of HER-2-positive complex metastatic breast melanoma, a brand new period has dawned within the treatment of this malignant illness.

Nanotechnology in Cancer (Micro and Nano Technologies)

Nanotechnology in melanoma covers present nanotechnology-based nanotherapeutics concerning gold nanoparticles, colloids, gels, magnetic nanoparticles, radiofrequency, gene treatment, organic debris, and the intermolecular interactions linked to nanoparticle established melanoma treatment in vivo. various melanoma kinds and destinations are thought of along the corresponding remedy kinds, and using imaging applied sciences and animal versions also are explored.

Additional info for Antifolate Drugs in Cancer Therapy (Cancer Drug Discovery and Development)

Sample text

Download PDF sample

Rated 4.91 of 5 – based on 5 votes